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Penile Injection Therapy

What is Penile Injection Therapy?

Penile Injection Therapy (PIT) is a shot (injection therapy) that you take for erectile dysfunction (ED). It is used when the nerves or blood vessels in the penis do not work normally. Did you know?

Does it work?

According to the AUA (American Urological Association), injection therapy is among the most effective nonsurgical treatment options for ED.

What are the advantages?

  • It works fast — PIT can give you an erection in just 5 to 20 minutes
  • You inject it yourself — The first shot will be given in your healthcare provider’s office. After that, you can inject PIT, or your partner can help you inject
  • It is a local injection — PIT contains an ingredient (alprostadil, PGE, Papaverine, or a combination). It helps keep blood vessels open and your blood flowing in the penis and not all over your circulation.


What kind of Instructions do patients have to follow after injection?

  • Do not use more than 3 times a week
  • Wait at least 24 hours between doses
  • Do not change the dose without talking to your healthcare provider
  • Do not use any leftover solution
  • Do not reuse the syringe or needle
  • Do not let anyone else use your syringes and medications
  • Do not stop taking any prescription medications unless your healthcare provider tells you to do so
  • If you have been advised not to have sex, do not use Penile Injection medicines
  • If you have an erection lasting more than 4 hours after injection, contact your healthcare provider right away


What can a patient expect after using PIT?

Expect Results: Over 80% of men experienced an erection

Maintaining an erection is just as important as getting one. PIT can help with both. That’s why you can feel confident when you ask your doctor about it. But that’s not the only reason why. Here are a few more:

  • Worked over 80% of the time in a study for men with erectile dysfunction
  • Can work in as fast as 5 to 20 minutes
  • It is a local injection
    • Only 3% of men found it painful enough to stop using it


Who should not use Penile Injection Therapy?

  • Any man who is allergic to alprostadil, papaverine, PGE or any injectable medication (the active ingredient) or anything else in the supplied compound.
  • Men who have been told by their healthcare provider not to have sex
  • Children, infants, and women
  • Men with conditions that might result in long-lasting erections that can damage the penis, such as:
    • Sickle cell anemia or sickle cell trait
    • Leukemia (white blood cell cancer)
    • Multiple myeloma (bone marrow cancer)
    • Abnormally shaped penis, a penis implant, or other problems of the penis


Can Penile Injected Therapy work for men with ED and other related health conditions?

Yes it can work in men with the following conditions:

  • Heart problems
  • Prostate problems
  • High blood pressure
  • Spinal cord injury
  • Diabetes
  • High cholesterol levels


What should I tell my urologist at Brooklyn Urology?

  • About all your medical conditions
  • About all your medicines, including over-the-counter medicines, vitamins, and herbal products
  • If you’ve ever had erections that lasted more than 4 hours
  • If you have sickle cell anemia, sickle cell trait, leukemia, or multiple myeloma
  • If you have a penis implant


What are possible Side Effects?

Like many prescription medications, there are some side effects:

An erection that lasts more than 4 hours is dangerous. If this happens to you, see a doctor right away. Without treatment, there could be lasting damage to the penis. You may lose potency.

The most common side effect is pain: 37% of men reported pain in the penis, at least once, after injectionIt was usually mild to moderate.  Few men stop the treatment because of pain.

Other side effects include:

  • Small amount of bleeding where the shot is given. This increases the risk of passing on diseases carried in blood, such as HIV (human immunodeficiency virus)
  • Small bumps or hard tissue in the penis
  • Infection. With any shot, there is a risk of infection
  • Low blood pressure and dizziness may be observed at higher doses


What other Precautions should I take?

  • Treatment should be discontinued in patients who develop penile angulation, cavernosal fibrosis (penile scars), or Peyronie’s disease.
  • Use offers no protection from the transmission of sexually transmitted diseases.